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Further research by Lingsi Zeng et al

Last Updated: November 20th, 2025

All these models developed histopathological changes, such as synovial hyperplasia, infiltration of immune cells (e.g., T cells, B cells, and macrophages), cartilage destruction, and bone erosion (17)

Regarding lipid metabolism, Rg reduces lipid uptake through suppression of CD36 expression (Wu et al., 2025) while activating the hepatic LKB1/AMPK/mTOR signaling pathway (Shi et al., 2024)