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Moreover, it has been found that TQ can directly modulate the activation of several signal transduction pathways including PI3K-Akt-mTOR that are frequently upregulated in various cancers and confer resistance to radiotherapy (Baskar et al., 2014

It has been well-established that mitochondrial dysfunction contributes to DKD, and the mitochondrion is a target for fighting DKD [42,43,44]

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