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Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism

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Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (Nos

Dysfunction of histone methyltransferases and deacetylases, especially when triggered by interferon-alpha-mediated signaling, may result in abnormal histone modifications

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