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AMPK inhibition, either pharmacologically using compound C or through siRNA-mediated knockdown, did not block the increase in GLUT1 expression after metformin treatment (Supplementary Fig

In the CNS, laminin deficiency leads to BBB breakdown, characterized by reduced pericyte coverage, leukocyte extravasation, and altered expressions of VE-cadherin, claudin-5, and occludin, underscoring laminin's role in maintaining BBB integrity [51, 66,67,68]

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