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NO pathway and FAK pathway for vascular response due to injury Why this matters: When injuries occur or repair is needed, decreasing inflammation and formation of new blood vessels is required to help the tissue heal

This wasn't just another molecule

The disease is characterized by: *Chronic lymphocytic infiltration of the thyroid gland *Elevated TPO antibodies (TPOAb) - present in over 90% of cases *Elevated thyroglobulin antibodies (TgAb) - present in 5080% of cases *Progressive thyroid fibrosis and loss of function *Eventual hypothyroidism requiring lifelong levothyroxine replacement The Oxidative Stress Signature of Hashimoto's The Antioxidants review (2021) confirmed that patients with Hashimoto's thyroiditis show a consistent pattern of oxidative stress markers: elevated malondialdehyde (MDA - a lipid peroxidation marker), reduced superoxide dismutase (SOD) activity, and critically, significantly decreased glutathione levels compared to healthy controls

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31 (9), R421r427

Oberley TB, Oberley LW (1997)