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Several distinct populations of microglia and macrophages have been described in the aging brain, including dark microglia (Bisht et al., 2016), IFN-responsive microglia (Kaya et al., 2022), and senescent-like microglia (Gross et al., 2025), underlying the heterogeneity of immune cell responses to aging-related stress

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Lastly, we would like to thank all the investigators whose studies we analyzed for making their data publicly available

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