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Specifically, the dysbiosis of gut microbiota and abnormal iron metabolism can promote each other, synergistically facilitating ferroptosis in OA

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However, there are dynamic scaffold-based 3D models used to study flow shear stress, such as polydimethylsiloxane (PDMS) only models, and others that combine the hydrogel cell culturing techniques with more complex microfluidic systems, namely PDMS-derived, PDMS-hydrogel hybrids, or pure hydrogel models [259]