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6.2.2 Therapeutic strategies targeting astrocytic ferroptosis Astrocytes, the most abundant glial cells in the central nervous system, play essential roles in supporting neuronal function, regulating antioxidant defense, and maintaining metabolic homeostasis

Comparison with previously reported cases Comparison with earlier reports offers additional mechanistic insight

Similarly, NEM or vinylpyridine is added to the glutathione recycling assay reaction mix, and the GSH content can be calculated by the subtraction of GSSG from total glutathione

NAC, a precursor of L-cysteine, is a powerful antioxidant that acts as a scavenger of free radicals, particularly oxygen-derived radicals 141

Also, because ALC was protective (ALC a key cofactor of -oxidation), we tested the idea that these brain cells may be utilizing non-carbohydrate substrates as the source of ATP for survival during METH-induced mishandling of glucose

Of equal concern is the fact that unregulated peptides may be contaminated with impurities, according to the FDA