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While high affinity is often desired, the synergy between independent metabolic pathwaysnamely GLP-1 (Glucagon-like peptide-1), GIP (Glucose-dependent insulinotropic polypeptide), and GCGR (Glucagon receptor)determines the ultimate metabolic outcome

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10.1186/s40643-017-0187-z 137

TMAO (trimethylamine N-oxide) is produced by gut bacteria from choline, lecithin, and L-carnitine-rich foods (mainly fish, meat, egg, and dairy)

DOI: 10.1016/S0166-2236(03)00032-8