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tissue measurement is the reference

The mean absolute bioavailability following intramuscular injection was approximately 14-19% in rats and 45-51% in beagle dogs, suggesting species-specific absorption characteristics relevant for dose translation to human applications

P450 uses molecular dioxygen of which one oxygen atom interacts with the substrate and a second oxygen atom, with the use of two electrons provided by NAD(P)H, is reduced to a water molecule

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Funding The works of JM and AM, cited in this review, have been supported by grants from the Ferdowsi University of Mashhad, the University of Tehran, and the Iranian National Elite Foundation

Insulin and insulin-like growth factors regulate ovarian steroid production as well and can increase androgen synthesis when elevated