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Up to 25% of all bacteria have selenoproteins in their genomes (the number varies from 0 to 57) and, thus, they require Se for their growth and metabolism (Kasaikina et al., 2011

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Observational studies Most of the early observational evidence from case-control and nested case-control studies suggested either null or inverse associations between selenium exposure and risk of site-specific cancers (67)

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GSH and necroptosis Necroptosis is a regulated form of necrotic cell death characterized by activation of RIPK3 and mixed lineage kinase domain-like pseudokinase (MLKL), with receptor-interacting serine/threonine kinase 1 (RIPK1) participating in many, but not all, necroptotic contexts

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