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Failure to clear senescent cells also lead to a pro-tumorigenic microenvironment characterized by chronic inflammation because of the SASP 12,25

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Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation

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The development of bispecific antibodies or dual CAR-T approaches could probably be a key factor for valuable therapies

Regulatory and governance considerations relevant to orthopaedic patients, including athletes, are summarized in Table 3