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Monnier M, et al

(44) determined that the four kavalactones, kawain, methysticin, yangonin and desmethoxyyangonin, did not inhibit alcohol dehydrogenase in vitro , suggesting that interaction of kavalactones with alcohol does not involve alcohol dehydrogenase inhibition

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placebo in patients with DPN or postherpetic neuralgia

These biomarkers were measured again at day 90, wherein it was found that Il-6 continued to decline, whereas CRP climbed again