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doi: 10.1038/nm.4490 258 SmeyersJ.BanchiE.-G.LatoucheM

M2-polarized tumor-associated macrophages promote epithelial-mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma

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16, 44 The glucocorticoid was used at a dose known to produce anti-arthritic actions

It is concluded that earlier trials are of short duration, on small sample sizes and did not document patient satisfaction, duration of depigmenting effect or need for repeat treatments

Thus, further research is warranted to determine if the SAAR-driven reduction in lactoylation prevents the inhibition of these enzymes and favors the diversion of glucose to asparagine