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Animal studies and observations in acromegalic patients demonstrate that GH-excess can have deleterious effects on kidney health, including glomerular hyperfiltration, renal hypertrophy, and glomerulosclerosis

The condition afflicts mainly males, although females can have symptoms too

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Thus, early placental development may be affected through dysregulated vascular development and function secondary to NAD(P)H oxidase-mediated altered gene expression [48, 213]

Les essais cliniques montrent un signal : la supplmentation orale 250-500 mg/jour pendant 4 12 semaines rduit modestement l'indice de mlanine, principalement dans les zones cutanes exposes au soleil

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