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10.1038/s41418-022-00941-0 7 ChenX.WangY.WangJ.-N.CaoQ.-C.SunR.-X.ZhuH.-J.et al (2022b)

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In addition, by reacting with oxidants such as superoxide anions, NO promotes cell injury and makes chondrocytes vulnerable to apoptosis induced by cytokines ( One study found that NO alone did not result in chondrocyte death but that NO triggered apoptosis when it reacted with O 2 - to produce chondrocytes (Nathan and Xie, 1994)