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In inflammation, IL-10 can reduce the antigen-presenting function by downregulating the expression of Mononuclear Cell Surface II major histocompatibility antigens (Class II major histocompatibility complex, MHC II), and inhibit inflammatory cell activation, migration, and adhesion by downregulating the activity of T cells

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Phase Phase 5 High escalation Weeks Weeks 1720 Dose 12.5 mg once weekly Notes Transitional