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Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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N is the number of times each experiment was repeated

doi: 10.1038/nature03445

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, et al

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