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Beta-3 Adrenergic Receptor (3-AR) Pathway Activation The primary documented mechanism of AOD-9604 in laboratory research models is activation of the beta-3 adrenergic receptor (3-AR), a G-protein-coupled receptor expressed predominantly in adipose tissue

doi: 10.1016/j.cell.2020.10.003

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Abstract Ferroptosis requires not only the accumulation of iron ions, but also changes in many ferroptosis-related regulators, including a decrease in GPX4 and inhibition of SLC7A11 for classical ferroptosis, a deletion of FSP1 or GCH1

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