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226 In a phase 2a study (NCT02413372), 16-week Pegbelfermin (BMS-986036, an FGF21 agonist) administration in patients with NASH and stage 13 fibrosis was associated with a significant reduction in hepatic steatosis measured by MRI-PDFF and improvement in lipid profiles, adiponectin concentration, and biomarkers of fibrosis and hepatic injury

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However, the procurement of endoscopic biopsy samples may prove difficult outside the context of intestinal diseases where endoscopy may be indicated for assessment of disease progression