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Oral glutathione increases tissue glutathione in vivo

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NOX-4, NADPH oxidase-4

Indeed, ACN possess high antioxidant capacity and could play a key role in the prevention of oxidative stress by scavenging ROS and free radicals and modulating endogenous defense system, as demonstrated in several in vitro and in vivo studies (Zafra-Stone et al., 2007)

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Br J Clin Pharmacol 71:2028 Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M (1999) Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury