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Also, some researchers suggested that Ingenol Mebutate (IM) is a modulator of eight PKC (Protein Kinase C isoenzyme) which involved in the signaling pathways including cell angiogenesis, cell invasion, cell survival/ cell death (survival/autophagy), cell proliferation and acts as either tumor suppressor or oncogenes

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Figure 3 ThMP kinase, which produces ThDP through ThMP phosphorylation and is known in thiamine-synthesizing organisms, has not been identified in animals