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As tau becomes hyperphosphorylated, its capacity to support microtubule assembly and stability diminishes, resulting in increased levels of unbound tau that may aggregate into tangles (if not secreted or degraded in the lysosome) [107]

The antioxidant activity of saffron is mainly due to crocin, and the synergistic effect of crocin and crocetin enhances oxygen diffusion and enhances ocular blood flow in the retina and choroid, which are crucial in the disease [230]

Lyophilization (freeze-drying): Preserves integrity and extends shelf life

Maier JA, Castiglioni S, Locatelli L, Zocchi M, Mazur A (2021) Magnesium and inflammation: advances and perspectives

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Roth E, N Manhart, B Wessner, Curr Opin Clin Nutr Metab Care , 2004