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A recent study by researchers from the Institute for Bioengineering of Catalonia and West China Hospital demonstrates a nanoparticle therapy that reversed Alzheimers disease in mice by repairing the bloodbrain barrier and restoring the brains ability to clear amyloid-

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This multiscale analysis will enable me to generate a mechanistic biological model bridging the synaptic and the behavioral level

In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

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