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A portion of pyruvate enters the mitochondria where it is used to fuel energy production via the citric acid cycle and oxidative phosphorylation (OXPHOS)

Cell lines The following pancreatic cancer cell lines were used for the in vitro studies: PA-TU-8902 (DSMZ, Braunschweig, Germany), Mia PaCa-2 and BxPC-3 (ATCC, Manassas, VA, USA)

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Glutathione is an antioxidant that consists of three different amino acids: cysteine, glutamic acid, and glycine

Wound healing applications, supporting recovery from procedures or injuries, may use higher concentrations under professional guidance

Collectively, our findings highlight the highly dynamic nature of the ferroptotic process in which modulatory signals can exert temporally opposing effects