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Inflammatory cytokines produced by intervertebral disc cells significantly contribute to low back and nerve root pain [20]

10.1007/s10545-016-9991-4 28 HuntA.HarringtonD.RobinsonS

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And the answer to this one has me talking about the law of diminishing returns , which is a concept widely used in economics and shows the relationship between investment (time, money, resources) and benefits