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A method of treating a PI3K mediated disorder in a subject, the method comprising administering a therapeutically effective amount of a compound according to any one of claims 1-51 or a pharmaceutical composition according to claim 52 to said subject
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In specific embodiments, the deliverable osmolarity/osmolality of the formulations (i.e., the osmolarity/osmolality of the formulation in the absence of gelling or thickening agents (e.g., thermoreversible gel polymers) is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of potassium or sodium salts) or the use of tonicity agents which renders the formulations endolymph-compatible and/or perilymph-compatible (i.e
