In dysbiosis, exosomes act as the transporter of high mobility group box 1 (HMGB1) protein from the intestine to the liver, triggering hepatic steatosis
Funding This work was supported by the International Athletics Foundation, the Swedish Research Council (2017-02051), the Swedish Research Council for Sport Science (P2018-0197 and P2019-0098), the Karolinska Institutet, the Swedish Military Research Authority (#AF 922 0916), and the Elisabeth and Gunnar Liljedahl Foundation
doi: 10.7326/m22-3469 259 MacreadieI
AMPK, adenosine monophosphate-activated protein kinase
Thus, it appears that in the presence of ChaC1 when glutathione and juglone form an adduct, this adduct would be inhibitory to the enzyme
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