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These findings suggest that targeting the IGF system may offer a promising strategy for CRC treatment, either by directly inhibiting IGF-1R or by modulating the activity of IGFBPs to restore balance and inhibit tumor progression [5, 8]

There are a wide range of endocrine factors that impact muscle mass and function, in particular IGF-1 signalling and androgen anabolic action and efforts to elucidate these are ongoing

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10.1080/14787210.2019.1656064 [DOI] [PubMed] [Google Scholar] Marshe V

Although much of the research has focused on larger peptides and growth factors [25, 26], smaller peptides, particularly tripeptides composed of only three amino acids, are now gaining attention for their efficiency