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In contrast, the CFA-induced (negative control) group exhibited marked arthritic changes characterized by joint space narrowing, irregular joint margins, periarticular bone erosions, cortical thinning, and mild soft-tissue swelling [Figure 14B]

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The optimal injection timing for the combination is consistent from week to week, ideally the same day and approximate time each week

Recent research has found that mutations in the TCA cycle enzymes SDH, FH, and IDH resulted in a dysfunction of the TCA cycle and defects in mitochondrial metabolism in a wide range of human cancers [7, 8]

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