Habib E, Linher-Melville K, Lin H-X, Singh G
The mechanisms of epilepsy caused by various mitochondrial diseases are different, and understanding its underlying pathological mechanism is very important to develop reasonable strategies for the treatment of mitochondrial-related epilepsy
When there is an imbalance in the body between the intensity of the synthesis of reactive oxygen species and the mechanisms responsible for antioxidation, oxidative stress occurs (18, 84)
We call this strategic synergy, and it's a cornerstone of advanced biological research
Consequently, the regulation of the expression of the membrane transporter SLC7A11, NADPH depletion because of glucose starvation, and subsequent disruption of the balance of thiol/disulfide bonds may serve as a common link between disulfidptosis and ferroptosis (Figure 2), potentially involving intersecting molecular pathways
J Biol Chem 234:815819 Shafer JA, Chiancone E, Vittorelli LM, Spagnuolo C, Machler B, Antonini E (1972) Binding of reduced cofactor to glutamate dehydrogenase
