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10.3390/ijms232213828 185 XuX

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However, despite robust pharmacodynamic potential in preclinical studies, the clinical translation of flavonoids remains hindered by multiple challenges, including poor solubility, low oral and dermal bioavailability, rapid systemic clearance, and insufficient toxicological profiling in humans

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142,143,144 In addition to MTL-CEBPA, MiNA Therapeutics has several saRNA candidates in preclinical development for undisclosed tumor types, metabolic diseases, and genetic disorders