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Streptococcus , Enterococcus , and Clostridium further metabolize simple substrates into volatile fatty acids (VFAs), ethanol, and hydrogen, which methanogens ultimately convert to methane 38

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Reduced levels of dopamine in the nucleus accumbens were also reported (99), alongside altered dopamine signaling (88)

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However, unlike a recent report where constitutive loss of IGF-1Rs specifically in the myocardium of male mice prevented age-related alterations to the heart 30 , late-life mAb treatment failed to preserve or restore these same parameters in male animals (Fig