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Using electroencephalography to measure the mices brain activity, the team also discovered that JB2 normalized neuronal excitability, or how neurons respond to stimuli with an electric charge, and seizure susceptibility

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These include (1) tetrahydrobiopterin (BH 4 ), synthesized by the GTP cyclohydrolase 1 (GCH1)6-pyruvoyl-tetrahydropterin synthase (PTS)sepiapterin reductase (SPR) metabolic pathway and regenerated by dihydrofolate reductase (DHFR) 11

ZnT1 is the most well-known member, as it is responsible for reducing intracellular zinc levels by exporting it across the plasma membrane [42]