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This enzymatic degradation substantially reduces the amount of intact glutathione that reaches the bloodstream, limiting the therapeutic concentration available to cells and tissues throughout the body

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These notably include Arabidopsis mutants deficient in the major leaf form of catalase (CAT2), in which conditionally increased H 2 O 2 availability through photorespiration drives reproducible changes in GSSG:GSH (Mhamdi et al., 2010a)

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