Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
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The usual approach includes a loading dose followed by regular maintenance therapy
however, their therapeutic use is hindered by off-target effects and the essential role of iron in homeostasis (Table 2)
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