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In the pancreas, GLP-1 receptor activation promotes insulin secretion and reduces glucagon secretion in a glucose-dependent manner

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Epidemiological studies show that low total BL levels (near or below the physiological lower limit of 0.41 mg/dL) are associated with an increased risk of neurological disorders (Vtek and Tiribelli, 2021), whereas physiological concentrations (0.11.2 mg/dL) inhibit NF-B signaling and mitigate lipopolysaccharide (LPS)-induced sepsis in murine models (Li et al., 2020)