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In particular, oxidative stress caused by reactive oxygen species (ROS) is a major contributor to the pathophysiology of neurodegenerative diseases

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The transporter SLC38A1 and the amino acid transporter SLC1A5-mediated glutamine uptake and subsequent glutaminase 2 (GLS2)-mediated glutamate production are required for cysteine-deprivation-induced ferroptosis [43, 44]

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