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Sirtuins are a family of nicotinamide adenine dinucleotide (NAD + )-dependent protein deacetylases that participate in multiple biological processes by deacetylating various types of proteins, including histones and nonhistone proteins, and seven different sirtuins, named SIRT1-7, have been identified 32

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Powers W.J., Rabinstein A.A., Ackerson T., Adeoye O.M., Bambakidis N.C., Becker K., Biller J., Brown M., Demaerschalk B.M., Hoh B., et al

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Around 20-40% of white or Hispanic people carry this mutation, which reduces enzyme function by 35%