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Because bioavailability varies, more efficient forms like liposomal or sublingual require lower daily doses to achieve similar health benefits

In the study, patients receiving ADI-PEG20 and docetaxel treatment displayed significant drop in plasma arginine level for the first 23 months of treatment, rise of arginine level, and ADI-PEG20 antibody at the later stage of treatment and tolerable adverse effect throughout the treatment [142]