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10.1046/j.1365-313X.2002.01476.x 129 YamaneK.MitsuyaS.TaniguchiM.MiyakeH

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When frataxin was absent, Fe-S synthesis was blocked, which not only interfered with the normal ETC but also forced cells to compensate for these effects by taking up additional iron, leading to iron overload and oxidative stress and triggering mitophagy [187]

It invites readers to see medicine not merely as a science of intervention, but as a discipline of perception, empathy, and awarenessan approach essential for thoughtful practice in the 21st century

consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphateparathyroid hormone (PTH) monitoringrather than positioning vitamin D as disease-modifying therapy for unselected CKD

Research indicates that approximately 80% of individuals with hypothyroidism have Hashimoto's anti bodies, but this statistic can vary based on environmental factors and individual health conditions