The specific mechanisms by which elevated homocysteine contributes to cardiovascular pathologies and whether interventions to lower homocysteine levels are beneficial remain areas of debate and investigation
Relationship between homocysteine and coronary artery disease
Commun Biol 5 , 326 (2022)
The actual mechanism is likely to occur via two sequential steps with semiquinone (SQ . ) and superoxide (O2 . ) intermediates
2.3.5 Epigallocatechin gallate (EGCG) EGCG, the principal catechin of green tea ( Camellia sinensis ), attenuates PsO-like inflammation through inhibition of STAT3 phosphorylation, NF-B signaling, and Th17 differentiation [52] In keratinocyte and IMQ mouse models, EGCG reduces IL-17/IL-22 production, oxidative stress, and keratinocyte hyperproliferation
Supplementary information Uncropped western blot membranes corresponding to Figs