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Recently, a therapy reducing the intestinal resorption of BAs has been approved

Preclinical models have shown that senolytic compounds like navitoclax or flavonoid-based combinations (e.g., fisetin) can reduce cartilage degradation and synovial inflammation by clearing senescent cells (Fernandez-Moreno et al., 2025

The conserved catalytic site comprises a tetrad of amino acids: Sec46, Gln81, Trp136 and Asn147, the latter being directly involved in catalysis

2018) to 500 U/L

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