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In order to improve clinical feasibility, the next generation of NP systems must have controlled biodistribution, reduced toxicity, and be administered less frequently (enhancing patient compliance)
In summary, encapsulating a oleophilic prodrug of Dex into PLGA-PEG NPs presents to be a prospective strategy for improving pharmacological profiles and reducing joint inflammation in mouse models of RA
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Results The study involved 44 postmenopausal women with rheumatoid arthritis, split into two groups of intervention ( n = 22) and control ( n = 22)
Welsh JW, Seyedin SN, Hofstetter WL, Ajani JA, Chang JY, Gomez DR, Swisher SG , Blum MA, Nguyen Q, Minsky BD, Erasmus J, Lee JH, Bhutani MS, Komaki RU
By isolating and examining the fluid inside these tumors, researchers found abundant storage of glutathione, confirming that tumors are aggressively consuming it as a nutrient source
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