Some species of plants have a variant of glutathione, homoglutathione, in which the glycine residue is replaced by b-alanine, due to an evolutionary change in specificity of the enzyme glutathione synthetase
Additionally, changes in red cell distribution width (RDW) have been observed, with substantial increases during acute COVID [344,345,346,347,348]
As already mentioned, GSTP1-1 is over-expressed in several cancers where it protects cells from cell death by inhibiting the activity of JNK or its upstream activation
5a,b and Extended Data Fig
We will discuss several interesting aspects of the two figures
Clinical trials show this effect requires sustained plasma glutathione concentrations above 1520 mol/L, which injectable forms achieve but oral forms rarely reach