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NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

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It is a nonspecific and uncontrolled process in which the resulting reactive oxygen species readily react with surrounding molecules, leading to intensification of the process, and the damage of the cell membrane

doi: 10.1093/rheumatology/keh688 205 GordonGLRaybouldMIJWongADeaneCM

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