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Acts partially through local GI mucosal pathways and partially via systemic absorption

Blood Coagul Fibrinolysis (2006) 17:8992

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Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

meaning that animal studies have shown some adverse effect or there are no well-controlled studies in humans, but potential benefits may warrant use despite potential risks