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It can also emerge during times when progesterone levels are manipulated, such as during In Vitro Fertilization (IVF)

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doi:10.1093/gerona/55.4.B170

Their review argued that the original sequence determination was performed once and not re-verified by modern methods, and that endogenous DSIP-like immunoreactivity in mammalian tissue may reflect related peptides rather than the synthetic nonapeptide as drawn (Kovalzon & Strekalova, 2006)