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A 12-week, randomized, double-blind, placebo-controlled, multicenter SF intervention trial was conducted in China with children (aged 315 years) with ASD in which 135 children were randomized to either SF or placebo treatments [198]

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doi: 10.3389/fmolb.2019.00091 114 Al-SowayanNS

(2024) further elaborated on these findings in a female rat model, demonstrating that NAC reverses CIS-induced increases in brain kynurenic acid, a metabolite associated with dysfunction in glutamatergic and cholinergic systems, while also doubling the GSH/GSSG ratio and preserving the density of cortical neurons [34]

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