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110 , 111 Non-Membrane Disrupting Mechanisms of AMPs Although the electrostatic interaction with tumor cell membrane and further disrupting action is the key of AMPs to kill the tumor cells, certain AMPs are accompanied by other mechanisms, such as inhibiting tumor DNA synthesis, destroying tumor cytoskeleton, inhibiting tumor angiogenesis, destroying tumor mitochondria, inducing tumor cell apoptosis or necrosis, and regulating immunity, as shown in Figure 3

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Clin Endocrinol

A frequent error is to take a mouse figure such as 1.44 mg/kg and multiply by human body weight to derive a human dose

This is a typical picture for the entire class of regenerative peptides: a strong signal from preclinical models (rodents, cell cultures), without full phase III clinical confirmation